This book explores the life and legacy of Francis Bacon, tracing how his vision of mastering nature through knowledge influenced centuries of scientific and technological progress. Using scattered writings as a foundation, the author reconstructs the so-called Baconian Program and traces its evolution through the Scientific Revolution, the Enlightenment, and the Industrial Revolution, ultimately reaching its zenith in the 20th century. Although Bacon’s ideas were extraordinarily successful, they also had unintended consequences that now challenge their original foundations. As the Baconian epoch comes to a close, the book reflects on the uncertainties of our time and explores emerging paradigms that could lead humanity into a post-Baconian future. This book will appeal to scholars, researchers, and students interested in the development of science and innovation studies, as well as anyone seeking to understand the historical roots and future implications of knowledge-driven progress.